Letter from DLF Co-Directors
Hal C. Lewis, Ph.D. & David Margulies, M.D.

The overarching goal of the Dan Lewis Foundation for Brain Regeneration Research (the DLF) has been, for the past five years, to support biomedical and biotechnological discoveries that will bring the promise of regenerating and repairing the seriously damaged brain into reality. We pursue this goal by sponsoring neuroscientific conferences, publishing a quarterly newsletter, funding early career scientists with the DLF Prize program, sharing promising research nationwide, and posting brain injury information on social media. We strongly believe that biomedical and biotechnological solutions and options for regenerating the seriously injured brain are not only possible but inevitable. The key question is not an “if” question but rather a “how soon” question.


Unfortunately, the current U.S. administration has adopted a somewhat negative stance towards the sciences in general, including the health sciences and biomedical research. With disregard for the way scientific knowledge accumulates, the budget slashers at DOGE, under the direction of the President and his Cabinet, have threatened serious cuts to NIH and NIMH research grants as well as to funds supporting students and faculty in neuroscience and biomedical training programs. Serious cuts to funding have already been made and further reductions can be expected. This short-sighted policy approach will significantly delay important discoveries across various scientific fields. Specifically, for DLF’s constituency, discoveries and related clinical trials that were potentially only a few years away may now be postponed by 5 to 10 years.


The DLF continues to stand in support of neuroscientific and biomedical programs, their students, trainees, faculty, and researchers that have contributed so much to the field of regenerating the damaged brain. If you visit our website—danlewisfoundation.org—you will see “Donate” buttons scattered throughout the content. Please consider a donation, no matter how small or large—to help us continue our work to catalyze progress in brain regeneration research and to urge policy makers to correct course and return to solid support of biomedical and biotechnological advances that will be of so much value to the American public and to persons with serious brain injuries worldwide.

Hal C. Lewis Ph.D.

DLF Co-Director

Donate

David Margulies, M.D,

DLF Co-Director

The word arpah is written in blue letters on a white background.
By Dan Lewis Foundation July 31, 2025
On July 10, 2025, the Advanced Research Projects Agency for Health (ARPA-H) announced a major initiative titled Functional Repair of Neocortical Tissue or FRONT. The announcement states “FRONT will pioneer a curative therapy for the more than 20 million adults in the US living with chronic neocortical brain damage from neurodegeneration, stroke, trauma, and other causes, which costs the country an estimated $800 billion per year. Worldwide, more than 200 million people live with debilitating after-effects of brain damage.”  A set of informational meetings about this program and a due date for outlines of potential proposals have been set for August. Full proposals are due by September 25, 2025. Complete instructions, specifications, and expectations are delineated in the ARPA-H FRONT announcement. The FRONT announcement includes a clear expectation that the successful brain regeneration methods that are discovered will be used in clinical trials with persons with brain injury by the fifth year of the program. The DLF lauds ARPA-H for initiating this program. We are discussing possibilities for playing a supportive role as proposals develop. This exciting program is congruent with the original overarching goals of the DLF and confirms the validity of its mission.
Photo of Dr. Justin Burrell
By Dan Lewis Foundation July 31, 2025
Dr. Burrell is a translational neuroengineer in the Departments of Neurosurgery and Oral & Maxillofacial Surgery at the University of Pennsylvania. His research integrates advanced neural repair strategies with clinical translation, focusing on axon protection, nerve fusion, and engineered neural tissue for neurotrauma recovery. Dr. Burrell has led the development of multiple first-in-field innovations—including the first large-animal model of nerve fusion, delayed axonal fusion protocols, and the first orally active axonal protectants—positioning him as a recognized leader in regenerative neurotechnologies. He is co-founder of Neurostorative LLC and plays a central role in several other platforms aimed at neural reconnection, long-term preservation, and bio-integrated prosthetic systems.