ARPA-H Announcement Seeks Research Projects in Brain Regeneration
Dan Lewis Foundation
The word arpah is written in blue letters on a white background.

On July 10, 2025, the Advanced Research Projects Agency for Health (ARPA-H) announced a major initiative titled Functional Repair of Neocortical Tissue or FRONT. The announcement states “FRONT will pioneer a curative therapy for the more than 20 million adults in the US living with chronic neocortical brain damage from neurodegeneration, stroke, trauma, and other causes, which costs the country an estimated $800 billion per year. Worldwide, more than 200 million people live with debilitating after-effects of brain damage.”



A set of informational meetings about this program and a due date for outlines of potential proposals have been set for August. Full proposals are due by September 25, 2025. Complete instructions, specifications, and expectations are delineated in the ARPA-H   FRONT announcement. The FRONT announcement includes a clear expectation that the successful brain regeneration methods that are discovered will be used in clinical trials with persons with brain injury by the fifth year of the program.


The DLF lauds ARPA-H for initiating this program. We are discussing possibilities for playing a supportive role as proposals develop. This exciting program is congruent with the original overarching goals of the DLF and confirms the validity of its mission.

A close-up of a glowing neural network with interconnected blue fibers and bright nodes against a dark background.

Restoring Communication in the Injured Brain

By Justin Burrell, PhD • March 17, 2026
A Neuroengineer’s Approach to Rebuilding Neural Circuits Note: Justin Burrell is the 2025 winner of the DLF Prize for Post-Doctoral Research. This article emphasizes the regenerative potential of improving the connectivity of replenished neural material.
Dan Lewis Foundation logo above the title: MAKING HEADWAY, An Evening of Scientific Advances and Musical Interludes PART I.

Making Headway: An Evening of Scientific Advances and Musical Interludes

By Hal Lewis • March 17, 2026
The Dan Lewis Foundation proudly presents Making Headway: An Evening of Scientific Advances and Musical Interludes DLF INFOTAINMENT FUNDRAISER WILL STREAM ON MARCH 26, 2026 The Dan Lewis Foundation will stream a program filled with up-to-date information about brain regeneration and terrific music on Thursday, March 26th. The event will be co-hosted by Dr. Jonathan LaPook, Chief Medical Correspondent for CBS News and Dr. David Margulies, biomedical and biotechnology writer and innovator and co-founder of the Dan Lewis Foundation. The musical performers will be Low Strung , a tremendous group of cellists who arrange and perform classic rock on their acoustic cellos and the Yale Symphony Orchestra playing two pieces from their 2025 season repertoire. The program will stream at 5:00 P.M. (Pacific), 6:00 P.M. (Mountain), 7:00 P.M. (Central), 8:00 P.M. (Eastern). This free program will be approximately one hour in length. The link to the event, which will activate on Thursday, March 26th at the above time(s) is: here . In late June, a similar program will be presented with additional information about the neuroscience and biotechnology of brain regeneration. This program will feature the Bill Hill Jazz Project and jazz pianist and Pulitzer Prize winning opera composer, Anthony Davis. Details of that event will be distributed in mid-June. We hope you will join us for this event. An informative and enjoyable program is promised!