The Dan Lewis Foundation for Brain Regeneration Research Announces 2024 Prize Open for Applications
Dan Lewis Foundation | Winter 2024

The Dan Lewis Foundation for Brain Regeneration Research (the DLF) is happy to announce the 2024 DLF Prize. This $20,000 prize will be awarded to an early career scientist in neuroscience, pharmacology, or biotechnology whose research record and future research plans align closely with one or more of the DLF’s current research priorities. These research priorities are:


  1. Research into pharmacological methods of reactivating or augmenting synaptogenesis
  2. Research into trials of repleting damaged cortex using derived cortical neurons
  3. Research into transcriptomic profiles of cortical neurons during the recovery phase post brain injury
  4. Research furthering the effective design of antisense oligonucleotides and/or other small molecule medicines to down-regulate inhibitors of regeneration in the cortex and spinal cord.


The successful applicant must be an early career scientist in neuroscience, molecular biology, pharmacology, or biotechnology. The “early career scientist” should be within 2-5 years post-completion of their doctoral degree. Full consideration is given to those scientists working in an academic setting (university or non-profit) or commercial setting (e.g., pharmaceutical or biotech company). The application is due March 31, 2024. Full details are available online through the linked application portal below. The winner of the DLF Prize 2024 will be notified in early June 2024.


https://www.danlewisfoundation. org/application-portal   


The winner of the 2023 DLF Prize, Dr. Roei Maimon has focused on stimulating the brain to create new neurons, an important process in mitigating the detrimental effects of neurodegenerative diseases and injuries. Most recently, Dr. Maimon and colleagues designed and executed tests using a certain type of biomolecular “medicines” called antisense oligonucleotides (ASOs) to generate glia-to-neuron conversion in the adult rodent nervous system. These new neurons matured and functionally integrated into endogenous circuits over a two month period, ultimately positively influencing the behavior of the mice.


Dr. Maimon has demonstrated his enthusiasm for the DLF and for the field of brain regeneration research by participating in several DLF activities designed to increase public awareness of our mission. We look forward to meeting the next DLF Prize winner and to supporting the development of young neuroscientists and their accomplishments in the field of brain regeneration.

By Dan Lewis Foundation | Spring 2024 11 Apr, 2024
Graham Dempsey, Ph.D., is a founder and Chief Scientific Officer (CSO) at Quiver Bioscience, a Cambridge, Massachusetts-based biotechnology company focused on the development of medicines for disorders of the nervous system. Dr. Dempsey and his team are working to develop treatments for some of the most challenging unsolved medical issues patients and their families face. Using advanced technologies in human stem cell biology, optogenetics, machine learning, and drug screening, progress is being made to develop medicines that will one-day treat conditions that have been largely untreatable. As the lead scientist for Quiver, formerly Q-State Biosciences, Dr. Dempsey enjoys working with world-class teams to invent, develop, and apply cutting-edge technologies to solve the most difficult challenges in biopharma for the betterment of patients. Dr. Dempsey’s inspiration to dedicate his professional life to science and medicine started at the early age of seven with the tragic loss of his father to an aggressive form of cancer, an experience that has deeply motivated him to this day. He completed his undergraduate studies at the University of Pennsylvania and his doctorate at Harvard University. As a graduate student in the biophysics program at Harvard Medical School, he co-developed ‘Stochastic Optical Reconstruction Microscopy’ or STORM , a light microscope with the ability to resolve nanometer (billionth of a meter, e.g. a hair is 100,000 nanometers thick) scale details of biological materials, an achievement that had been thought to be impossible for over a century. STORM has enabled what researchers call ‘super-resolution imaging’ for visualizing the intricate details of life’s most fundamental unit, the cell. Understanding the inner workings of a cell provides a path to a deeper understanding of the ways in which life is constructed and diseases can manifest. The technology was commercialized by Nikon Instruments for researchers worldwide. Dr. Dempsey left academic science to join Q-State Biosciences as the first hired employee with the goal of bringing advanced technologies developed at Harvard to the study of the brain. The brain, arguably the most complex structure in the known universe, works through electrical communication between brain cells or neurons. This communication is disrupted in all brain disorders but has been near impossible to study for the purposes of effectively developing medicines. Dr. Dempsey and his team over the course of ten years built a technology system that creates human brain models from patient stem cells (i.e. a ‘disease-in-a-dish’) and converts electrical activity of those brain cells into light signals that can be detected with ultra-sensitive microscopes. The resulting signals are analyzed using machine learning to find the patterns of how electrical activity is altered in disease, which can be used to find medicines that correct those changes. The team at Quiver is deploying this technology to take on previously untreatable brain conditions, including rare genetic diseases, such as certain seizure and neurodevelopmental disorders, to common conditions, such as chronic pain and Alzheimer’s disease. Dr. Dempsey’s passion outside of science starts with his family, his wife (and high school sweetheart) and three young daughters, be it traveling the globe to experience new cultures (or simply stare at the ocean), cooking elaborate meals on a Saturday evening, night-time reading of novels to his daughters, or attending live music around Boston. As a native of NJ, he celebrates his roots with visits to family near the Jersey Shore and, whenever possible, attendance at Springsteen concerts and Giants games. Dr. Dempsey is an avid student of history’s great entrepreneurs, spending the sparse remaining minutes of the day reading biographies and listening to podcasts, looking to extract every bit of learning towards taking on the challenges of building a great business while staying true to his family, his Quiver teammates, and his professional mission.
By Dan Lewis Foundation | Spring 2024 11 Apr, 2024
Sheryl Suzanne Nibbs, a legal secretary in a top law firm, started the process of becoming a paralegal as she approached her 40th birthday. She was fancy in her appearance, always making sure her hair, nails, and clothing were in order, a well-kept person, an avid traveler, and her mother’s best friend.
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